Sequences/structures unique to IFN-τ could allow for alternative IFN/receptor interactions and may explain the differences in biologic function.
The antiviral effects observed in this study reveal that IFN-τ has potent antipapillomavirus activity. Increases in p53 concentrations correlated with the observed decreases in E6 mRNA and protein levels. All three IFN were capable of increasing the cellular concentration of wild-type p53 tumor suppressor with the magnitude IFN-τ > IFN-α2a > IFN-αB/D. IFN-τ was comparable to IFN-α2a in decreasing intracellular levels of E6 and E7, and IFN-αB/D was more effective than IFN-α2a in suppressing E7 levels. Pc Clone Ex Lite Drivers Freeware Virtual PC Clone v.1.0 Using virtualization Technologie the goal of Virtual PC Clone will be to install any pc based operating system on a host computer. Nontumorigenic human keratinocytes, HuKc/HPV-16d-2C (d-2C), treated with recombinant human IFN-α2a (Roferon), a human recombinant alpha IFN hybrid, alpha B/D (IFN-αB/D), or ovine IFN-τ were evaluated for their effects on the levels of E6 and E7 expression.
The effects of interferon-τ (IFN-τ) on tumor suppressor factors and virus oncoprotein expression were compared with two other type I IFN in human papillomavirus (HPV-16)-transformed cells.
0 kommentar(er)
